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KMID : 0939920090410010053
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대한암학회지
2009 Volume.41 No. 1 p.53 ~ p.55
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A Case of Gemcitabine and Cisplatin AssociatedPosterior Reversible Encephalopathy Syndrome
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Kwon Eun-Jin
Kim Se-Won
Kim Kwang-Ki
Seo Hyung-Suk
Kim Do-Yeun
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Abstract
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A 58-year-old female receiving gemcitabine and cisplatin chemotherapy for stage IVgallbladder cancer developed the clinicoradiologic syndrome, posterior reversibleencephalopathy syndrome (PRES). Just before the 4th gemcitabine chemotherapy cycle, shewas admitted to the hospital with complaints of headache, dizziness, and generalized tonic-clonic seizures. A MRI was performed on the day when the seizure developed, and thefindings showed patchy cortical and subcortical T2 hyperintensity without enhancement thatinvolved both occipital and parietal lobes. Phenytoin loading and maintenance was startedfor prevention of recurrent seizures, which was successful. The follow-up brain MRIobtained 10 days after the seizure attack showed completely resolved radiologic findings.After the MRI findings revealed complete resolution, phenytoin maintenance was stopped.Even with discontinuation of phenytoin, she had no seizures or other clinical manifestations.
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KEYWORD
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Cisplatin, Gemcitabine, Posterior reversible encephalopathy syndrome (PRES)
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